Proximal tubule development

Across TCGA patient cohorts, RNA activity of the Proximal tubule development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA9, CLSTN1, and KHNYN, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proximal tubule development activity versus ANXA9 in UCEC (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANXA9 →	-0.530	-0.574	.007	<.001	3	3
OV	CLSTN1 →	+1.147	+0.756	<.001	<.001	3	3
LUAD	KHNYN →	+0.204	+0.444	.004	.004	3	3
HNSC	TREML2 →	+0.512	+0.163	.001	.003	3	3
CCRCC	RN7SL775P →	+0.715	+0.559	<.001	<.001	3	3
GBM	RPL22 →	-0.306	-0.558	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072014 vs ANXA9 — UCEC

Explore this scatter interactively →