Proximal tubule development

Across TCGA cell cohorts, RNA activity of the Proximal tubule development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2M, EML2, and HOOK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBE2M grouped by Proximal tubule development-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	UBE2M →	-0.659	-1.265	<.001	.004	3	5
KIDNEY	EML2 →	-1.461	-1.185	.001	.006	3	5
SKIN	HOOK1 →	+1.017	+1.117	.007	.001	3	4
SOFT_TISSUE	TOR1AIP1 →	-0.791	-1.182	.006	.007	3	4
LUNG_NSCLC_LUAD	RSU1 →	-1.118	-0.901	<.001	<.001	3	4
BLOOD_Leukemia	ACTB →	-0.578	-0.858	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBE2M by Proximal tubule development activity — BONE

Explore this box plot interactively →