Glomerular epithelium development

Across TCGA patient cohorts, RNA activity of the Glomerular epithelium development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GUCY1B1, FRZB, and GUCY1A1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerular epithelium development activity versus GUCY1B1 in UCEC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GUCY1B1 →	+0.473	+0.065	<.001	<.001	3	9
OV	FRZB →	+0.954	+0.063	<.001	.001	2	9
OV	GUCY1A1 →	+0.495	+0.062	.001	.001	3	8
OV	CYGB →	+0.606	+0.080	.004	<.001	3	7
BRCA	RSU1 →	+0.477	+0.086	<.001	<.001	3	7
OV	SEPTIN4 →	+0.681	+0.080	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072010 vs GUCY1B1 — UCEC

Explore this scatter interactively →