Glomerular epithelium development

Across TCGA patient cohorts, RNA activity of the Glomerular epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS2, ALOX5AP, and ANKRD65, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerular epithelium development activity versus RGS2 in BRCA (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RGS2 →	+0.844	+0.597	.002	.005	3	5
COAD	ALOX5AP →	+0.820	+0.384	<.001	.002	3	4
CCRCC	ANKRD65 →	+0.406	+0.638	.002	<.001	3	4
LSCC	PTGIS →	+0.909	+0.464	<.001	.001	3	4
BRCA	SNED1-AS1 →	+0.575	+0.948	<.001	<.001	3	4
PDAC	CHPF →	+0.378	+0.951	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072010 vs RGS2 — BRCA

Explore this scatter interactively →