Glomerular epithelium development

Across TCGA cell cohorts, RNA activity of the Glomerular epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF544, ATP5F1A, and TBC1D2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF544 grouped by Glomerular epithelium development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF544 →	-1.214	-1.115	.006	<.001	3	5
CNS	ATP5F1A →	+0.477	+0.792	<.001	.001	3	5
PANCREAS	TBC1D2 →	-1.348	-0.846	.005	.008	3	5
SOFT_TISSUE	FOSL2 →	-2.594	-1.434	<.001	.005	3	4
SKIN	NDUFA2 →	-0.379	-0.964	.001	.005	3	4
SKIN	CCN1 →	-1.869	-1.557	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF544 by Glomerular epithelium development activity — SKIN

Explore this box plot interactively →