Glomerular epithelium development

Across TCGA cell cohorts, RNA activity of the Glomerular epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT2A, RRAS2, and EHD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerular epithelium development activity versus MT2A in OVARY (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MT2A →	+3.699	+0.382	<.001	<.001	3	6
OVARY	RRAS2 →	+1.055	+0.291	.001	.001	3	6
OVARY	EHD2 →	+3.286	+0.383	<.001	<.001	3	6
LARGE_INTESTINE	MYH9 →	+0.908	+0.262	.003	.004	3	6
OVARY	SERPINE1 →	+5.285	+0.446	.003	<.001	3	5
OVARY	INHBA →	+1.706	+0.243	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072010 vs MT2A — OVARY

Explore this scatter interactively →