Nephron development

Across TCGA patient cohorts, RNA activity of the Nephron development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYGB, ARHGEF17, and PRKG1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nephron development activity versus CYGB in UCEC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYGB →	+0.747	+0.043	<.001	.006	3	9
CCRCC	ARHGEF17 →	+0.451	+0.055	<.001	<.001	3	9
UCEC	PRKG1 →	+0.808	+0.054	<.001	<.001	3	9
BRCA	RAI14 →	+0.467	+0.039	<.001	<.001	3	9
BRCA	TIMP2 →	+0.604	+0.028	<.001	<.001	3	9
CCRCC	FMNL3 →	+0.400	+0.055	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072006 vs CYGB — UCEC

Explore this scatter interactively →