Nephron development

Across TCGA cell cohorts, RNA activity of the Nephron development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRN3, HMMR, and CACNB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RRN3 grouped by Nephron development-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RRN3 →	-0.721	-0.238	.003	<.001	3	3
SOFT_TISSUE	HMMR →	-0.858	-0.301	.002	.008	3	3
LUNG_NSCLC_LUSC	CACNB2 →	-0.275	-0.270	.008	<.001	2	4
LUNG_NSCLC_LUSC	JPT2 →	-1.232	-0.249	.009	.003	3	3
OESOPHAGUS	AHCY →	+0.821	+0.313	.003	.001	3	3
LIVER	CYP4V2 →	-2.175	-1.385	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RRN3 by Nephron development activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →