Nephron development

Across TCGA cell cohorts, RNA activity of the Nephron development pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BOLA2B, BOLA2, and ERBIN, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nephron development activity versus BOLA2B in STOMACH (Pearson r = -0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	BOLA2B →	-2.324	-0.378	<.001	<.001	3	13
STOMACH	BOLA2 →	-2.324	-0.378	<.001	<.001	3	13
LIVER	ERBIN →	+1.664	+0.406	.001	.001	3	11
BREAST	ITGA3 →	+2.779	+0.532	<.001	<.001	3	11
LUNG_NSCLC_LUSC	DDI2 →	-2.514	-0.440	.002	.002	3	11
OESOPHAGUS	PEBP1 →	-2.059	-0.377	.004	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072006 vs BOLA2B — STOMACH

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