Multivesicular body sorting pathway

Across TCGA patient cohorts, RNA activity of the Multivesicular body sorting pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLIC2, HM13, and RPL30, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multivesicular body sorting pathway activity versus CLIC2 in LSCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLIC2 →	+0.522	+0.040	.001	.002	3	6
GBM	HM13 →	-0.300	-0.033	.001	.001	3	6
BRCA	RPL30 →	-0.192	-0.035	<.001	<.001	3	5
LSCC	RPS16 →	-0.217	-0.047	<.001	<.001	3	5
BRCA	SBSPON →	+0.604	+0.023	.006	.003	3	5
BRCA	XPO5 →	-0.474	-0.030	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071985 vs CLIC2 — LSCC

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