Multivesicular body sorting pathway

Across TCGA patient cohorts, RNA activity of the Multivesicular body sorting pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL20-DT, NDUFAF4, and MIR17HG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multivesicular body sorting pathway activity versus MRPL20-DT in UCEC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL20-DT →	-0.505	-0.130	.002	.006	3	5
LSCC	NDUFAF4 →	-0.710	-0.175	<.001	<.001	3	5
BRCA	MIR17HG →	-0.675	-0.206	<.001	<.001	3	5
LUAD	ZCCHC3 →	-0.306	-0.140	.005	.004	3	5
LSCC	RBM28 →	-0.392	-0.143	.002	<.001	3	4
UCEC	SPC25 →	-0.778	-0.174	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071985 vs MRPL20-DT — UCEC

Explore this scatter interactively →