Multivesicular body sorting pathway

Across TCGA cell cohorts, RNA activity of the Multivesicular body sorting pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN1, ABHD17C, and KIAA1522, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSPAN1 grouped by Multivesicular body sorting pathway-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TSPAN1 →	+3.773	+0.364	<.001	<.001	3	5
URINARY_TRACT	ABHD17C →	+1.502	+0.250	.002	.005	3	5
URINARY_TRACT	KIAA1522 →	+1.756	+0.298	.002	<.001	3	5
URINARY_TRACT	IL17RE →	+2.443	+0.298	<.001	<.001	3	5
URINARY_TRACT	SH3TC2 →	+2.427	+0.275	.002	<.001	3	5
URINARY_TRACT	B3GNT3 →	+3.865	+0.257	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSPAN1 by Multivesicular body sorting pathway activity — PANCREAS

Explore this box plot interactively →