Extracellular exosome assembly

pathway activity — cross-omics
GO:0071971Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Extracellular exosome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NAA50, TSR1, and STAM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVNAA50 →-0.269-0.056.001.00136
COADTSR1 →-0.249-0.022.001.00336
GBMSTAM →+0.291+0.076.006.00135
LSCCUPF2 →+0.190+0.046<.001<.00135
LUADHGS →+0.128+0.040<.001.00235
OVBUD23 →-0.413-0.055.002.00235
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration