"Mitotic sister chromatid cohesion, centromeric"

Across TCGA patient cohorts, RNA activity of the "Mitotic sister chromatid cohesion, centromeric" pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNOT3_S299, RFC1_T506, and RFC2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Mitotic sister chromatid cohesion, centromeric" activity versus CNOT3_S299 in UCEC (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CNOT3_S299 →	+0.617	+0.098	<.001	<.001	3	10
PDAC	RFC1_T506 →	+1.019	+0.067	<.001	<.001	3	9
LSCC	RFC2 →	+0.487	+0.063	<.001	<.001	3	9
UCEC	RFC3 →	+0.365	+0.118	<.001	<.001	3	9
OV	RPL12_S38 →	+1.286	+0.088	<.001	<.001	3	9
LUAD	RRM2 →	+1.015	+0.079	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071962 vs CNOT3_S299 — UCEC

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