"Mitotic sister chromatid cohesion, centromeric"

Across TCGA patient cohorts, RNA activity of the "Mitotic sister chromatid cohesion, centromeric" pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMMR, SUV39H2, and KIF14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Mitotic sister chromatid cohesion, centromeric" activity versus HMMR in LUAD (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HMMR →	+0.910	+0.257	<.001	<.001	3	6
LSCC	SUV39H2 →	+0.664	+0.225	.001	.005	3	5
LUAD	KIF14 →	+0.994	+0.218	.001	<.001	3	5
LUAD	SGO1 →	+0.506	+0.220	.003	<.001	3	5
LSCC	CENPH →	+0.843	+0.236	<.001	.001	3	5
LSCC	SKA1 →	+0.935	+0.313	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071962 vs HMMR — LUAD

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