"Mitotic sister chromatid cohesion, centromeric"

Across TCGA cell cohorts, RNA activity of the "Mitotic sister chromatid cohesion, centromeric" pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMC2, HTRA2, and S1PR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EMC2 grouped by "Mitotic sister chromatid cohesion, centromeric"-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	EMC2 →	-0.520	-0.228	.004	.005	3	4
KIDNEY	HTRA2 →	-0.654	-0.172	.002	.001	2	4
LIVER	S1PR2 →	-1.360	-0.286	.004	.005	3	3
KIDNEY	MCUR1 →	+0.888	+0.218	.007	<.001	3	3
OESOPHAGUS	MON2 →	+0.704	+0.126	.002	.003	3	3
BLOOD_Myeloma	AP3M2 →	-2.195	-0.383	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EMC2 by "Mitotic sister chromatid cohesion, centromeric" activity — LIVER

Explore this box plot interactively →