Protein deubiquitination involved in ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Protein deubiquitination involved in ubiquitin-dependent protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1R, C1S, and DAPK3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein deubiquitination involved in ubiquitin-dependent protein catabolic process activity versus C1R in GBM (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C1R →	+0.467	+0.050	<.001	<.001	3	6
GBM	C1S →	+0.560	+0.054	<.001	.003	3	5
OV	DAPK3 →	+0.334	+0.034	<.001	.004	3	5
UCEC	NHLRC2 →	+0.232	+0.064	.008	.002	3	5
HNSC	GATAD2B →	+0.266	+0.087	.001	.002	3	5
HNSC	OTUD7B →	+0.278	+0.094	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071947 vs C1R — GBM

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