Protein deubiquitination involved in ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Protein deubiquitination involved in ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFNG, ARFGAP2, and RN7SL704P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein deubiquitination involved in ubiquitin-dependent protein catabolic process activity versus MFNG in LSCC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MFNG →	-0.455	-0.513	.003	.003	3	4
UCEC	ARFGAP2 →	+0.500	+0.503	.002	.004	3	3
UCEC	RN7SL704P →	-1.089	-0.570	.003	.001	3	3
UCEC	RN7SL784P →	-0.730	-0.624	.002	<.001	3	3
HNSC	FGD3 →	-0.596	-0.505	<.001	<.001	3	3
HNSC	ATF7IP2 →	+0.601	+0.529	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071947 vs MFNG — LSCC

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