Urea transmembrane transport

Across TCGA patient cohorts, RNA activity of the Urea transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BPI, RETN, and S100A12, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urea transmembrane transport activity versus BPI in PDAC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	BPI →	+1.510	+0.271	<.001	.001	3	7
PDAC	RETN →	+0.915	+0.232	<.001	.004	3	6
PDAC	S100A12 →	+1.654	+0.286	<.001	<.001	3	6
LSCC	CSTB →	+0.500	+0.226	<.001	<.001	3	6
PDAC	SMARCC2_S347 →	-0.969	-0.246	<.001	.001	3	6
PDAC	CEACAM8 →	+1.694	+0.206	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071918 vs BPI — PDAC

Explore this scatter interactively →