Urea transmembrane transport

Across TCGA patient cohorts, RNA activity of the Urea transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KAAG1, RADX, and HNRNPA1P58, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urea transmembrane transport activity versus KAAG1 in CCRCC (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KAAG1 →	+0.445	+0.594	.008	.001	3	3
CCRCC	RADX →	-0.702	-0.299	<.001	.009	3	3
CCRCC	HNRNPA1P58 →	+0.392	+0.385	.001	<.001	3	3
UCEC	LINC02250 →	+0.544	+0.974	.007	.001	3	3
PDAC	DCDC2 →	+1.113	+0.231	<.001	.001	3	3
LSCC	CA4 →	+0.924	+0.873	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071918 vs KAAG1 — CCRCC

Explore this scatter interactively →