Determination of liver left/right asymmetry

Across TCGA patient cohorts, RNA activity of the Determination of liver left/right asymmetry pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1CB, MRPL42, and STK3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Determination of liver left/right asymmetry activity versus PPP1CB in BRCA (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PPP1CB →	-1.527	-0.176	<.001	.002	3	4
COAD	MRPL42 →	-0.349	-0.653	.003	.008	3	4
PDAC	STK3 →	-0.432	-0.161	.001	.003	3	3
PDAC	SP4 →	-0.395	-0.194	.003	.001	3	3
PDAC	AHR →	-0.742	-0.234	<.001	<.001	3	3
PDAC	YWHAE →	-0.316	-0.170	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071910 vs PPP1CB — BRCA

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