Determination of liver left/right asymmetry

Across TCGA cell cohorts, RNA activity of the Determination of liver left/right asymmetry pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRNP48, PYROXD1, and ZSCAN20, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNRNP48 grouped by Determination of liver left/right asymmetry-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SNRNP48 →	-0.970	-0.720	<.001	.009	3	3
SOFT_TISSUE	PYROXD1 →	-0.726	-1.474	.002	.002	3	3
LUNG_SCLC	ZSCAN20 →	-0.908	-0.771	<.001	.005	3	3
LUNG_SCLC	ZMYM4 →	-0.735	-0.727	.001	.009	3	3
LUNG_SCLC	UBN2 →	-0.930	-0.791	<.001	.003	3	3
LUNG_SCLC	BSDC1 →	-1.329	-1.333	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNRNP48 by Determination of liver left/right asymmetry activity — LUNG_SCLC

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