Determination of digestive tract left/right asymmetry

Across TCGA patient cohorts, RNA activity of the Determination of digestive tract left/right asymmetry pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFT140, IFT74, and RPL12_S38, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Determination of digestive tract left/right asymmetry activity versus IFT140 in BRCA (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IFT140 →	+0.560	+0.113	<.001	<.001	3	7
BRCA	IFT74 →	+0.386	+0.099	<.001	<.001	3	7
UCEC	RPL12_S38 →	-0.725	-0.117	<.001	<.001	3	6
UCEC	SPA17 →	+0.834	+0.201	<.001	.001	3	6
LUAD	SPATA18_S507 →	+1.037	+0.085	<.001	.002	3	6
UCEC	WDR19 →	+0.508	+0.154	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071907 vs IFT140 — BRCA

Explore this scatter interactively →