Positive regulation of protein serine/threonine kinase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein serine/threonine kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAB1, SNTB2_S222, and TBC1D2B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein serine/threonine kinase activity activity versus STAB1 in GBM (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STAB1 →	+0.574	+0.044	<.001	<.001	3	8
GBM	SNTB2_S222 →	+0.641	+0.028	<.001	<.001	3	7
GBM	TBC1D2B →	+0.329	+0.053	<.001	<.001	3	7
COAD	TLN1 →	+0.326	+0.018	<.001	.004	3	7
GBM	CD14 →	+0.579	+0.035	.001	.003	3	7
LSCC	ACTN1 →	+0.370	+0.032	.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071902 vs STAB1 — GBM

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