Positive regulation of protein serine/threonine kinase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein serine/threonine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIGLEC10, HSPB8, and LINC02783, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein serine/threonine kinase activity activity versus SIGLEC10 in OV (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SIGLEC10 →	+0.618	+0.507	.007	.007	3	3
OV	HSPB8 →	+0.838	+0.526	.006	.003	3	3
OV	LINC02783 →	+0.054	+0.506	.005	.005	3	3
PDAC	MIR4632 →	-0.863	-0.230	<.001	.002	3	3
LUAD	OR2A4 →	+0.894	+0.290	<.001	<.001	3	3
COAD	ABCA8 →	+0.713	+0.794	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071902 vs SIGLEC10 — OV

Explore this scatter interactively →