Positive regulation of protein serine/threonine kinase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein serine/threonine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLOD1, LRRC6, and SNX24, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein serine/threonine kinase activity activity versus PLOD1 in LUNG_SCLC (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLOD1 →	-1.146	-0.724	.001	.003	3	5
SOFT_TISSUE	LRRC6 →	+2.226	+1.454	<.001	.001	3	5
BLOOD_Lymphoma	SNX24 →	-1.254	-0.606	.005	.002	3	5
BLOOD_Leukemia	FAM162A →	+0.523	+0.672	.005	.001	3	4
STOMACH	FAM114A1 →	-1.931	-1.097	.008	.007	3	4
BLOOD_Myeloma	FECH →	-1.366	-1.266	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071902 vs PLOD1 — LUNG_SCLC

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