Negative regulation of protein serine/threonine kinase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein serine/threonine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEAK1, HNRNPA1P49, and DDX17, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein serine/threonine kinase activity activity versus PEAK1 in THYM (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	PEAK1 →	+1.364	+0.055	<.001	<.001	3	33
DLBC	HNRNPA1P49 →	+0.825	+0.047	<.001	.001	3	33
ACC	DDX17 →	+1.152	+0.025	<.001	<.001	3	32
DLBC	FNBP4 →	+1.303	+0.051	<.001	<.001	3	32
DLBC	CBL →	+1.440	+0.054	<.001	<.001	3	32
SCLC	SYNE1 →	+1.077	+0.099	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071901 vs PEAK1 — THYM

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