Negative regulation of protein serine/threonine kinase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein serine/threonine kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S432, TLN1, and WAS, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein serine/threonine kinase activity activity versus SEPTIN4_S432 in UCEC (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEPTIN4_S432 →	+0.538	+0.049	<.001	.006	3	8
COAD	TLN1 →	+0.382	+0.033	<.001	<.001	3	8
GBM	WAS →	+0.459	+0.037	<.001	<.001	3	8
GBM	DAB2 →	+0.448	+0.028	<.001	<.001	3	8
BRCA	DOCK11 →	+0.307	+0.027	.003	.001	3	8
GBM	AIF1 →	+0.636	+0.040	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071901 vs SEPTIN4_S432 — UCEC

Explore this scatter interactively →