Negative regulation of protein serine/threonine kinase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein serine/threonine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCDHB7, ZCRB1, and SDHAF4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein serine/threonine kinase activity activity versus PCDHB7 in LSCC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PCDHB7 →	+0.288	+0.092	.007	.008	3	3
LSCC	ZCRB1 →	-0.365	-0.133	.002	.003	3	3
LSCC	SDHAF4 →	-0.542	-0.187	<.001	<.001	3	3
LSCC	TPI1P3 →	-0.422	-0.129	.004	.003	3	3
OV	VSIR →	+0.508	+0.167	.001	.003	3	2
OV	UNC5A →	+0.907	+0.163	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071901 vs PCDHB7 — LSCC

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