Negative regulation of protein serine/threonine kinase activity

pathway activity — cross-omics
GO:0071901Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein serine/threonine kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SECISBP2L, SHROOM2_S1173, and GRAMD2B_S72, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein serine/threonine kinase activity activity versus SECISBP2L in COAD (Pearson r = -0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADSECISBP2L →-0.575-1.188<.001<.00132
LSCCSHROOM2_S1173 →-0.931-0.230<.001<.00132
OVGRAMD2B_S72 →+1.371+0.217<.001<.00132
LSCCHSH2D_S175 →+0.983+0.164<.001.00232
BRCANCOA7_S162 →+0.855+0.201<.001<.00132
OVNEFM_S620 →-1.350-0.157<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071901 vs SECISBP2L — COAD

Per-sample scatter of Negative regulation of protein serine/threonine kinase activity activity vs SECISBP2L in COAD.

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Exploration