Negative regulation of protein serine/threonine kinase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein serine/threonine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRTAP, SH3KBP1, and VEGFB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRTAP grouped by Negative regulation of protein serine/threonine kinase activity-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CRTAP →	-2.186	-0.393	<.001	<.001	3	4
BLOOD_Lymphoma	SH3KBP1 →	-3.192	-0.363	.001	<.001	3	4
LUNG_NSCLC_LUSC	VEGFB →	-1.115	-1.747	<.001	<.001	3	4
LUNG_NSCLC_LUSC	PSORS1C1 →	-1.780	-1.835	<.001	<.001	3	4
KIDNEY	CCN1 →	+1.283	+1.454	.001	<.001	3	3
LIVER	RBMS1 →	+1.280	+1.762	.008	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRTAP by Negative regulation of protein serine/threonine kinase activity activity — LUNG_SCLC

Explore this box plot interactively →