Negative regulation of protein serine/threonine kinase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein serine/threonine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYGL, EPB41L5, and RAB15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein serine/threonine kinase activity activity versus PYGL in BLOOD_Leukemia (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PYGL →	+3.979	+0.247	<.001	<.001	3	4
BLOOD_Leukemia	EPB41L5 →	-1.517	-0.260	<.001	<.001	3	4
BLOOD_Leukemia	RAB15 →	-1.587	-0.248	.002	.001	3	4
BLOOD_Leukemia	C16orf87 →	-0.723	-0.254	<.001	<.001	3	4
KIDNEY	FANK1 →	+1.690	+0.454	.005	.001	3	4
SOFT_TISSUE	SLC38A6 →	+1.220	+0.173	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071901 vs PYGL — BLOOD_Leukemia

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