Regulation of protein serine/threonine kinase activity

Across TCGA cell cohorts, RNA activity of the Regulation of protein serine/threonine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFB3, AHCY, and PKIB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDUFB3 grouped by Regulation of protein serine/threonine kinase activity-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NDUFB3 →	-0.317	-0.177	.003	.001	3	4
LUNG_SCLC	AHCY →	-0.675	-0.169	<.001	.001	3	4
LIVER	PKIB →	+4.476	+0.313	.002	.003	3	3
LUNG_NSCLC_LUAD	MYL5 →	+0.704	+0.145	.005	.007	3	3
LARGE_INTESTINE	ARID5B →	+1.435	+0.170	<.001	.003	3	3
LARGE_INTESTINE	PANK1 →	+0.896	+0.150	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDUFB3 by Regulation of protein serine/threonine kinase activity activity — SKIN

Explore this box plot interactively →