Regulation of protein serine/threonine kinase activity

Across TCGA cell cohorts, RNA activity of the Regulation of protein serine/threonine kinase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPTAN1, CYP21A1P, and TBX4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPTAN1 grouped by Regulation of protein serine/threonine kinase activity-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPTAN1 →	+0.194	+0.164	.002	.003	2	4
LUNG_NSCLC_LUSC	CYP21A1P →	-0.500	-0.176	.001	.009	3	3
BLOOD_Leukemia	TBX4 →	-0.218	-0.242	.002	.001	3	3
BLOOD_Leukemia	SERHL2 →	-0.118	-0.192	.002	.002	3	3
BLOOD_Leukemia	RGPD2 →	-0.115	-0.228	.007	.002	3	3
PANCREAS	AIRE →	-0.121	-0.627	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPTAN1 by Regulation of protein serine/threonine kinase activity activity — LARGE_INTESTINE

Explore this box plot interactively →