Regulation of protein serine/threonine kinase activity

Across TCGA cell cohorts, RNA activity of the Regulation of protein serine/threonine kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP11B, TMEM117, and GTF2H4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein serine/threonine kinase activity activity versus ATP11B in KIDNEY (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ATP11B →	-0.974	-0.378	.007	.003	3	4
LARGE_INTESTINE	TMEM117 →	-0.716	-0.471	.004	.008	3	3
STOMACH	GTF2H4 →	-0.600	-0.179	.005	.004	3	3
PANCREAS	DHRS4 →	+0.957	+0.828	<.001	.007	3	3
BLOOD_Leukemia	WDR93 →	+0.123	+0.139	<.001	<.001	3	3
BLOOD_Lymphoma	P4HB →	-1.442	-0.355	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071900 vs ATP11B — KIDNEY

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