DNA biosynthetic process

Across TCGA patient cohorts, RNA activity of the DNA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YJU2, DUOXA1, and DUS3L, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA biosynthetic process activity versus YJU2 in COAD (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	YJU2 →	-0.415	-0.250	.004	.004	3	1
COAD	DUOXA1 →	-0.625	-0.347	.001	.008	3	1
COAD	DUS3L →	-0.729	-0.241	.001	.007	3	1
COAD	ANKRD29 →	-0.913	-0.275	.007	<.001	3	1
COAD	MGAT5B →	-0.080	-0.254	.008	<.001	3	1
COAD	KRT75 →	-1.327	-0.372	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071897 vs YJU2 — COAD

Explore this scatter interactively →