DNA biosynthetic process

Across TCGA cell cohorts, RNA activity of the DNA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPACA6, ORC3, and NUP58, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPACA6 grouped by DNA biosynthetic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SPACA6 →	-1.871	-0.229	.002	.007	3	5
OESOPHAGUS	ORC3 →	-0.625	-0.094	.007	.007	3	4
OESOPHAGUS	NUP58 →	-0.860	-0.175	.001	.003	3	4
OESOPHAGUS	POLR2D →	-0.721	-0.123	.004	.002	3	4
BONE	KIAA1841 →	-0.815	-0.215	.008	.007	3	4
LARGE_INTESTINE	CHN1 →	-1.874	-0.192	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPACA6 by DNA biosynthetic process activity — LIVER

Explore this box plot interactively →