DNA biosynthetic process

Across TCGA cell cohorts, RNA activity of the DNA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATAD5, RBM12B, and THOC1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA biosynthetic process activity versus ATAD5 in BLOOD_Lymphoma (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ATAD5 →	+1.126	+0.068	<.001	<.001	3	20
LUNG_NSCLC_LUSC	RBM12B →	+1.314	+0.069	.003	.007	3	20
UPPER_AERODIGESTIVE_TRACT	THOC1 →	+1.420	+0.097	<.001	<.001	3	19
URINARY_TRACT	CEP152 →	+1.242	+0.084	<.001	<.001	3	19
LUNG_NSCLC_LUSC	S100PBP →	+0.947	+0.075	.004	.001	3	19
BLOOD_Lymphoma	CIT →	+1.406	+0.073	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071897 vs ATAD5 — BLOOD_Lymphoma

Explore this scatter interactively →