DNA biosynthetic process

Across TCGA cell cohorts, RNA activity of the DNA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NASP, ITGB1, and SLC25A43, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA biosynthetic process activity versus NASP in BLOOD_Leukemia (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NASP →	+0.633	+0.143	<.001	<.001	3	6
BONE	ITGB1 →	-1.934	-0.261	.002	.008	3	6
BONE	SLC25A43 →	-2.314	-0.281	.006	.002	3	5
BLOOD_Leukemia	CD63 →	-1.056	-0.151	<.001	<.001	3	5
PANCREAS	LMAN2 →	-0.689	-0.253	.006	.006	3	5
PANCREAS	AFMID →	+0.892	+0.217	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071897 vs NASP — BLOOD_Leukemia

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