Protein localization to adherens junction

Across TCGA patient cohorts, RNA activity of the Protein localization to adherens junction pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCDC6, MPP7, and DLG5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to adherens junction activity versus CCDC6 in LSCC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CCDC6 →	+0.289	+0.068	<.001	.008	3	6
BRCA	MPP7 →	+0.615	+0.071	<.001	<.001	3	6
BRCA	DLG5 →	+0.421	+0.070	<.001	<.001	3	5
BRCA	DLG5_S264 →	+0.602	+0.082	<.001	<.001	3	5
LSCC	CBFB →	-0.272	-0.072	<.001	<.001	3	5
LSCC	MTMR6 →	-0.153	-0.060	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071896 vs CCDC6 — LSCC

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