Protein localization to adherens junction

Across TCGA cell cohorts, RNA activity of the Protein localization to adherens junction pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC34, CPT1A, and GEMIN5, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC34 grouped by Protein localization to adherens junction-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CDC34 →	+0.148	+0.184	<.001	.003	3	2
BREAST	CPT1A →	-0.190	-0.208	<.001	.001	3	2
LUNG_NSCLC_LUAD	GEMIN5 →	+0.620	+0.280	.006	<.001	3	2
LUNG_NSCLC_LUAD	SYNGR4 →	-0.189	-0.232	.007	.009	3	2
LUNG_NSCLC_LUAD	TOMM40 →	-0.550	-0.256	.002	.003	3	2
LUNG_NSCLC_LUAD	WDR76 →	+0.167	+0.278	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC34 by Protein localization to adherens junction activity — BREAST

Explore this box plot interactively →