Protein localization to adherens junction

Across TCGA cell cohorts, RNA activity of the Protein localization to adherens junction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMD11, SDF2L1, and SYS1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to adherens junction activity versus PSMD11 in LUNG_SCLC (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PSMD11 →	+1.530	+0.305	.001	.009	3	2
LUNG_SCLC	SDF2L1 →	+1.907	+0.305	.004	.009	3	2
LUNG_SCLC	SYS1 →	-0.659	-0.306	.003	.008	3	2
BREAST	TJP1 →	+1.283	+0.274	<.001	<.001	3	2
BREAST	VSIR →	+3.077	+0.179	<.001	.001	3	2
BREAST	COQ5 →	-0.858	-0.212	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071896 vs PSMD11 — LUNG_SCLC

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