Odontoblast differentiation

Across TCGA patient cohorts, RNA activity of the Odontoblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMP2, COL1A2, and FKBP7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Odontoblast differentiation activity versus TIMP2 in OV (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TIMP2 →	+0.584	+0.056	<.001	<.001	3	8
COAD	COL1A2 →	+0.535	+0.040	.006	<.001	3	8
OV	FKBP7 →	+0.518	+0.056	<.001	<.001	3	8
OV	RCN3 →	+0.602	+0.057	<.001	<.001	3	7
OV	ZCCHC24 →	+0.688	+0.071	.007	.003	3	7
OV	C1QA →	+0.688	+0.067	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071895 vs TIMP2 — OV

Explore this scatter interactively →