Odontoblast differentiation

Across TCGA cell cohorts, RNA activity of the Odontoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA1B, FEN1, and SSRP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUBA1B grouped by Odontoblast differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TUBA1B →	+0.716	+0.501	.003	.002	3	4
BONE	FEN1 →	+0.831	+0.172	.006	.006	3	4
BONE	SSRP1 →	+0.741	+0.195	.002	.001	3	4
BONE	INSIG2 →	-0.924	-0.188	.009	.008	3	3
LARGE_INTESTINE	ACTRT3 →	-1.142	-0.895	<.001	.004	3	3
SOFT_TISSUE	RPLP1 →	+0.558	+0.374	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUBA1B by Odontoblast differentiation activity — SOFT_TISSUE

Explore this box plot interactively →