Odontoblast differentiation

Across TCGA cell cohorts, RNA activity of the Odontoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLF2, TERF2IP, and WIPI1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Odontoblast differentiation activity versus SLF2 in BREAST (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLF2 →	-0.771	-0.221	.002	<.001	3	4
BONE	TERF2IP →	+0.801	+0.212	.005	.002	3	4
STOMACH	WIPI1 →	+1.906	+0.408	<.001	.008	3	4
SOFT_TISSUE	CRMP1 →	+1.442	+0.185	.009	.007	2	4
BREAST	SLC29A1 →	-1.617	-0.221	<.001	<.001	3	3
STOMACH	HRK →	-1.120	-0.408	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071895 vs SLF2 — BREAST

Explore this scatter interactively →