Macrophage apoptotic process

Across TCGA patient cohorts, RNA activity of the Macrophage apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCR7, IL10RA, and THEMIS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage apoptotic process activity versus CCR7 in HNSC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCR7 →	+0.586	+0.246	.006	<.001	3	7
LSCC	IL10RA →	+0.916	+0.330	<.001	<.001	3	6
LSCC	THEMIS2 →	+0.837	+0.257	<.001	.003	3	6
LSCC	P2RY8 →	+0.848	+0.322	<.001	<.001	3	6
GBM	CR1 →	+0.745	+0.362	<.001	<.001	3	6
BRCA	IGHG1 →	+2.076	+0.295	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071888 vs CCR7 — HNSC

Explore this scatter interactively →