Macrophage apoptotic process

Across TCGA cell cohorts, RNA activity of the Macrophage apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN2A, SIRT1, and IRF7, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN2A grouped by Macrophage apoptotic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CDKN2A →	-0.279	-0.955	<.001	.007	3	11
CNS	SIRT1 →	-0.219	-0.925	<.001	<.001	3	5
BREAST	IRF7 →	-0.220	-0.975	<.001	<.001	3	5
PANCREAS	DYRK1A →	-0.131	-0.689	.001	.008	3	5
CNS	CTSL →	-0.165	-0.719	.001	.008	3	5
OVARY	GCSHP3 →	-0.219	-1.221	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN2A by Macrophage apoptotic process activity — BLOOD_Leukemia

Explore this box plot interactively →