Leukocyte apoptotic process

Across TCGA patient cohorts, RNA activity of the Leukocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, IL2RB, and LILRB1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte apoptotic process activity versus CSF2RB in SCLC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	CSF2RB →	+1.990	+0.134	<.001	<.001	3	33
SKCM	IL2RB →	+2.166	+0.055	<.001	<.001	3	33
SKCM	LILRB1 →	+1.823	+0.056	<.001	<.001	3	33
CHOL	AKNA →	+2.044	+0.066	<.001	<.001	3	33
CHOL	GZMK →	+2.662	+0.059	<.001	<.001	3	33
SCLC	IL18R1 →	+1.240	+0.124	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071887 vs CSF2RB — SCLC

Explore this scatter interactively →