Leukocyte apoptotic process

Across TCGA patient cohorts, RNA activity of the Leukocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3CD-AS1, CD40, and MS4A4A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte apoptotic process activity versus PIK3CD-AS1 in HNSC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PIK3CD-AS1 →	+0.553	+0.718	<.001	.002	3	4
PDAC	CD40 →	+0.414	+0.835	.004	<.001	3	4
PDAC	MS4A4A →	+0.436	+0.853	<.001	<.001	3	3
LSCC	TUG1 →	-0.770	-0.330	.002	<.001	3	3
COAD	SH3BGRL2 →	-0.382	-0.808	.002	.001	2	4
UCEC	APOBEC3C →	+0.640	+0.175	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071887 vs PIK3CD-AS1 — HNSC

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