Adenylate cyclase-activating adrenergic receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-activating adrenergic receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX56, RNMT, and XPO5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-activating adrenergic receptor signaling pathway activity versus DDX56 in LSCC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DDX56 →	-0.321	-0.062	<.001	.001	3	8
BRCA	RNMT →	-0.337	-0.059	<.001	<.001	3	7
BRCA	XPO5 →	-0.581	-0.069	<.001	<.001	3	7
GBM	MSH2 →	-0.373	-0.050	.003	.003	3	7
GBM	MSH6 →	-0.434	-0.055	.001	.001	3	7
OV	SPARCL1_S295 →	+1.028	+0.052	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071880 vs DDX56 — LSCC

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